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稀释的年轻果多醇-复合物的结构修饰及其对与口臭相关的细菌的抗菌活性

Yuan Wang¹, Mengyu Li¹, Ruisheng Liao¹

¹Department of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an, PR China; National Research and Development Center of Apple Processing Technology, Xi'an, PR China.

International journal of biological macromolecules

|February 23, 2025

概括

与果多 (YAP) 复合的显著增强了其抗菌活性,对抗P. gingivalis,P. gingivalis是口臭的关键细菌. YAP-Zn在破坏细菌细胞膜和诱导细胞死亡方面表现出卓越的有效性,这表明它在牙科护理应用中的潜力.

科学领域:

材料科学:金属有机复合物的表征.
微生物学:对口腔病原体具有抗菌活性.

背景情况:

炎通常是由像 Porphyromonas gingivalis 这样的细菌引起的.
聚烯,如年轻果 (YAP) 的聚烯,具有抗菌性质.
金属复合可以提高天然化合物的稳定性和有效性.

研究的目的:

为了合成和描述年轻果多醇 (YAP),酸 (CGA) 和化的复合物.
评估YAP-Zn对 Porphyromonas gingivalis 的抗菌活性.
研究YAP-Zn对P. gingivalis细胞膜的作用机制.

主要方法:

使用SEM,UV-Vis,FTIR,1H NMR和TGA进行复杂的合成和表征.
确定针对P. gingivalis的最小抑制度 (MIC).
评估细菌活力,膜透性和膜潜力.

主要成果:

离子以1:3的比例与YAP复合,改善了热稳定性.
与YAP (8.00 mg/mL) 相比,YAP-Zn对P. gingivalis的MIC (2.00 mg/mL) 显著较低.
YAP-Zn诱导了更大的P. gingivalis细胞死亡,增加了膜的透性,并降低了膜潜力.

结论:

用离子复合YAP可增强其对P. gingivalis的抗菌功效.
YAP-Zn表现出一种强大的作用机制,涉及细胞膜破坏.
在牙科护理产品中,YAP-Zn作为口臭相关细菌的抗菌剂具有前途.

关键词:

具有抗菌活性,具有抗菌活性.标志性描述标志性描述热稳定性热稳定性稀释的年轻果多醇-复合物

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