皮肤平衡在腺炎补充性病变中受损:一项比较研究
A Soto-Moreno1, N Delgado-Moya1, M Sánchez-Díaz2
1Dermatology Unit, Hospital Universitario Virgen de las Nieves Instituto de Investigación Biosanitaria IBS, Granada, España.
Actas dermo-sifiliograficas
|February 23, 2025
概括
补腺炎 (HS) 病变显示皮肤屏障功能受损,水分流失和红色增加. 这种功能障碍与疾病严重程度相关,为客观HS评估提供了潜力.
科学领域:
- 皮肤病学 皮肤病学
- 皮肤生理学 皮肤生理学
- 慢性炎症疾病 慢性炎症疾病
背景情况:
- 补腺炎 (HS) 是一种慢性炎症性皮肤疾病,影响皮肤平衡.
- 了解与HS相关的皮肤功能变化对于疾病管理和客观评估至关重要.
- 目前关于HS皮肤平衡和屏障功能的知识有限.
研究的目的:
- 为了比较皮肤平衡和表皮屏障功能在病变与健康的皮肤HS患者.
- 调查HS严重程度和皮肤屏障参数之间的关系.
主要方法:
- 横截面研究设计. 截面研究设计.
- 在HS病变中使用经过验证的工具评估皮肤平衡和表皮屏障功能.
- 与健康的周围皮肤对照进行比较.
主要成果:
- 与健康的皮肤相比,在HS病变 (结节,,排水道) 中观察到增加的皮肤间脱水 (TEWL) 和红疹.
- 结节中的TEWL与IHS4阶段相关;排水道中的TEWL与吸烟相关.
- 随着Hurley阶段的更高,人们注意到TEWL增加的趋势.
结论:
- HS病变显示了与炎症活动严重程度相关的表皮屏障功能障碍.
- 结果可能有助于开发客观的HS分类系统.
- 结果可以为开发针对性药物输送车辆和HS管理的包裹提供信息.
相关概念视频
Skin Diseases and Disorders
2.8K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
2.8K
Hypodermis
3.9K
The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
3.9K
Chronic Bowel Disorders: Introduction
378
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
378
Clinical Applications of Epidermal Stem Cells
2.7K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.7K
Inflammatory Bowel Disease II: Crohn's Disease
158
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
158
Factors Affecting the Risk of Infection
10.7K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
10.7K


