基于金属有机框架的药物输送系统的进展
M T Khulood1, U S Jijith2, P P Naseef3
1College of Pharmaceutical Sciences, Government Medical College, Kozhikode 673008 Kerala, India; Kerala University of Health Sciences, Medical College P.O., Thrissur 680596 Kerala, India.
International journal of pharmaceutics
|February 23, 2025
概括
金属有机框架 (MOF) 提供先进的药物递送系统 (DDS),具有高负载能力和受控释放. 本综述探讨了MOF结构,合成和在向和刺激响应疗法中的应用.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
- 生物医学工程 生物医学工程
背景情况:
- 金属有机框架 (MOF) 是由金属离子和有机连接剂构成的晶体多孔材料.
- MOF具有可调节的结构,大表面积和可调节的孔径,使其对各种应用具有前景.
- 它们的独特特性正在被探索用于先进的生物医学用途,特别是在药物输送中.
研究的目的:
- 综合审查MOF作为先进药物输送系统 (DDS) 的应用.
- 详细介绍基于MOF的DDS的结构,合成和药物加载机制.
- 讨论基于MOF的DDS的设计策略,治疗应用,挑战和混合方法.
主要方法:
- 对与药物输送相关的MOF合成和表征技术的文献综述.
- 分析各种MOF系统的药物载荷能力和释放概况.
- 检查表面功能化和对有针对性和受控的药物释放的刺激反应策略.
- 调查MOF与其他材料的集成,以形成混合DDS.
主要成果:
- MOFs具有很高的药物载荷能力和受控释放能力.
- 像表面功能化这样的设计策略可以实现有针对性的交付,而对刺激有反应的MOF可以控制释放.
- MOFs有效地提供各种治疗剂,包括小分子,,蛋白质,核酸和癌症药物.
- 基于混合MOF的DDS显示出更好的交付性能.
结论:
- MOFs代表了开发先进药物输送系统的多功能平台.
- 基于MOF的DDS提供高效率,有针对性的交付和受控释放的功能.
- 需要进一步的研究来应对稳定性,生物相容性和临床翻译的可扩展性等挑战.
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