在等待名单上的时间是肺移植后90天死亡率的独立风险因素
Enora Atchade1, Vincent Bunel-Gourdy2, Nathalie Zappella3
1APHP, CHU Bichat-Claude Bernard, DMU PARABOL, 46 rue Henri Huchard, 75018 Paris, France; Inflammation Research Center, Inserm UMR 1149, Paris, France.
Anaesthesia, critical care & pain medicine
|February 23, 2025
概括
肺移植等待时间较长会增加90天死亡风险. 等待100天以上的LT患者面临更多并发症和延长ICU停留时间.
科学领域:
- 移植手术 移植手术
- 肺部病理学 肺部病理学
- 关键护理医学 关键护理医学
背景情况:
- 虽然研究了移植候选人的等待名单死亡,但基于等待名单时间 (TWL) 的肺移植 (LT) 受益人的短期结果不太清楚.
- 这项研究调查了TWL对LT接受者的早期死亡率和并发症的影响.
研究的目的:
- 确定肺移植等待名单 (TWL) 上长时间和短期死亡率之间的关系.
- 评估TWL分层的肺移植接受者的早期术后并发症.
主要方法:
- 在2016年1月至2022年8月期间,对242名肺移植接受者进行了观察性,单心,回顾性研究.
- 进行了单变量和多变量逻辑回归分析.
- 卡普兰-梅尔曲线和日志等级测试分析了90天和一年的生存率.
主要成果:
- 长时间的TWL (>100天) 与较高的败血症休克率,3级初级移植功能障碍和KDIGO 3急性损伤有关.
- 长期TWL患者经历了更长时间的重症监护室 (ICU) 住院治疗.
- 多变量分析确定TWL是90天死亡率的独立风险因素 (OR1.02,p=0.032).
结论:
- 肺移植等候名单上的时间是90天死亡率的独立预测指标.
- 肺移植接受者等待时间超过100天,患术后并发症的风险更高.
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