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光盘大小和外围状视网膜神经纤维层在青光眼中变薄

Takashi Nishida¹, Vincent Q Pham¹, Sasan Moghimi¹

¹Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California.

Ophthalmology. Glaucoma

|February 23, 2025

概括

更大的光盘大小与更快的circumpapillary视网膜神经纤维层在青光眼患者中变薄有关. 这种关联无论种族如何都适用,这表明光盘大小是格洛科马进展的关键因素.

科学领域:

眼科医生眼科眼科
玻璃眼研究研究玻璃眼研究
神经眼科神经眼科

背景情况:

玻璃眼是导致不可逆转失明的主要原因.
光盘大小和种族是影响青光眼病进展的潜在因素.
了解这些因素对于早期检测和管理至关重要.

研究的目的:

为了研究光盘大小与环囊状视网膜神经纤维层 (cpRNFL) 稀薄率之间的关系.
为了确定种族是否会影响患有青光眼和前临界青光眼的患者的这种关联.

主要方法:

一项观察性队列研究包括553名患者的841只眼睛,使用光学连贯断层扫描 (OCT) 至少进行4次访问和2年的随访.
使用多变量线性混合效应建模来评估光盘大小对cpRNFL稀释的影响,并控制相关的共变量.
眼睛的基线视野平均偏差大于-14dB被排除在外,以减轻地板效应.

主要成果:

总共分析了841只眼睛,平均随访时间为5.3年.
经过对共变量进行调整后,更大的光盘尺寸与更快的cpRNFL稀释 (每0.1 mm2增加0.03 μm/年; P = 0.034) 有显著的关联.
根据种族或其与光盘大小的相互作用,没有发现cpRNFL稀释的显著差异.

结论:

较大的光盘大小是一个独立的预测器更快的circumpapillary视网膜神经纤维层在青光眼中变薄.
虽然种族可能会影响玻璃眼风险,但当控制光盘大小和其他因素时,它似乎不是光盘变薄率的重要预测因素.

关键词:

眼光障碍眼光障碍眼光障碍眼光障碍视觉光盘是指光盘中的光盘.一个进步的进步.种族种族种族种族

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