系统性红斑狼肺部表现的综合风险评估:一项基于韩国人口的大规模纵向研究
Bo-Guen Kim1, Jiyeong Kim2, Yeonghee Eun3
1Division of Pulmonary Medicine, Department of Internal Medicine, Kangbuk Samsung Hospital, Seoul, Korea (the Republic of).
系统性红斑狼 (SLE) 患者面临显著更高的风险发展肺表现,包括肺高血压和间歇性肺病. 这项研究强调了与普通人群相比,SLE患者的肺病风险增加.
科学领域:
- 类风湿病学 类风湿病学
- 肺部病理学 肺部病理学
- 流行病学 流行病学
背景情况:
- 肺部干扰是系统性红斑狼 (SLE) 的常见并发症.
- 在SLE患者与普通人群中肺部表现的确切比较风险尚未确立.
研究的目的:
- 与匹配的对照组相比,对被诊断患有SLE的个体进行肺部表现的风险调查和量化.
主要方法:
- 从韩国国家医疗保险服务数据 (2009-2017年) 中确定了6,074名新诊断的SLE患者 (年龄≥20岁) 的队列.
- 选择了60,740个年龄和性别匹配的对照组,没有先前的肺部问题 (1:10比).
- 平均9.3年的随访数据被分析为肺部表现的发病率.
主要成果:
- 在SLE队列中,肺部表现的发生率为每1000人年15.2,对照组为4.5.
- 患有SLE的患者患肺部症状的风险增加了3.3倍 (aHR为3.26).
- 肺高血压 (aHR 14.66) 和间歇性肺病 (aHR 9.58) 的风险显著增加,以及其他疾病,如肺部疾病,肺栓塞,结核病,ARDS/出血和肺癌.
结论:
- 患有SLE的人患肺部症状的风险大大增加.
- 肺高血压和间歇性肺病在SLE患者中具有特别高风险的肺并发症.
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