继续服用甲托雷克沙特会增加患有下肢缺陷骨折的患者的骨折风险
Barbara Hauser1, Andrew Merriman2, Jonathan Foley3
1Rheumatic Diseases Unit, NHS Lothian, Western General Hospital, Edinburgh, UK; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Cancer, Western General Hospital, Edinburgh, UK.
Annals of the rheumatic diseases
|February 23, 2025
概括
在缺陷骨折后继续使用甲状腺素显著增加了随后骨折的风险. 停止使用甲托雷克萨特对于最大限度地降低未来骨折风险和改善患者的治疗结果至关重要.
科学领域:
- 类风湿病学 类风湿病学
- 整形外科 整形外科 整形外科
- 药理学 药理学是指药理学的学科.
背景情况:
- 甲索特雷克萨特 (MTX) 与缺陷骨折有关,称为甲索特雷克萨特骨质病 (MTXO).
- 以前的报道强调MTXO,但继续MTX对未来骨折风险的影响仍然不清楚.
研究的目的:
- 为了确定MTXO不足骨折后继续MTX是否会影响后续骨折的风险.
- 评估在继续或停止MTX的患者中骨折愈合和疼痛结果.
主要方法:
- 对33名患有MTXO下肢缺陷骨折的患者的回顾性审查.
- 评估了在继续与停止MTX的患者中随后的骨折发生和愈合.
主要成果:
- 在骨折后继续使用MTX导致进一步缺乏或严重骨质疏松性骨折 (95.2%) 的高发病率.
- 停止使用MTX显著减少了随后的骨折 (27.3%对95.2%,P<.001).
- 停用MTX在愈合期间改善了疼痛和承重能力.
结论:
- 在患有MTXO不足骨折的患者中,继续MTX与额外骨折的实质性风险有关.
- 识别MTXO和停止MTX对于减轻未来骨折风险至关重要.
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