在非脱髓化大脑皮层中,突触功能的星调节依赖于MyD88信号,在毒性脱髓化模型中是如此

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Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates
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Melanie Lohrberg1,2, Lena Sünke Mortensen3,4, Carolina Thomas1,4

  • 1Department of Neuropathology, University Medical Center Göttingen, Göttingen, Germany.

Journal of neuroinflammation
|February 23, 2025
PubMed
概括

在渐进的多发性硬化症 (MS) 中,天生的免疫细胞 (如星球细胞) 导致大脑小脑突触功能障碍在正常出现的灰质中 (NAGM),独立于脱髓化. 这突出了MS神经系统衰退的新疗法目标.

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