动脉硬是代谢功能障碍相关的脂肪性肝病的并发症:系统性审查和元分析
Alexios Giannakodimos1, Evangelos Oikonomou1, Panteleimon Pantelidis1
13rd Department of Cardiology, Sotiria Chest Disease Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Expert review of gastroenterology & hepatology
|February 24, 2025
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 与更大的动脉硬性有关. 即使考虑到常见的心脏代谢风险因素,如肥胖和高血糖,这种关联仍然存在.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的健康问题.
- 动脉硬是心血管事件的独立预测因素.
- MASLD与动脉硬之间的关系需要进一步研究.
研究的目的:
- 系统地审查和元分析MASLD与动脉硬之间的关联.
- 探索影响这种关系的潜在心脏代谢辅因子.
主要方法:
- 在主要的科学数据库 (PubMed/Medline,Embase,Scopus,Web of Science) 中进行了全面的文献搜索.
- 包括观察性研究,比较患有MASLD的成年人与健康个体的动脉硬指数 (例如,PWV,AIx).
- 27项研究有资格进行元分析.
主要成果:
- 与对照人群相比,患有MASLD的患者表现出 significantly增加的阴道 - 骨PWV (MD: 0.96 m/s).
- 马斯尔德也与较高的腕PWV (MD: 78.14 cm/s) 和AIx (MD: 3.85%) 相关.
- 这些发现无论身体质量指数,甘油三,高密度胆固醇,缩血压和禁食血葡萄糖,都保持显著.
结论:
- MASLD与动脉硬度增加有显著的相关性.
- 这种关联独立于常见的心脏代谢风险因素.
- 通过动脉硬化,MASLD代表了心血管疾病的潜在危险因素.
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