骨形态遗传蛋白10在前毛囊性肺高血压患者中增加
Aida Llucià-Valldeperas1,2, Jessie van Wezenbeek1,2, Joanne A Groeneveldt1,2
1Amsterdam UMC location Vrije Universiteit Amsterdam, PHEniX laboratory, Department of Pulmonary Medicine, Amsterdam, The Netherlands.
右心房骨形态蛋白10 (BMP10) 在心房拉伸和压力驱动的前毛囊性肺高血压 (precPH) 中升高. 降低这种压力会降低BMP10的活性,这表明它是一个潜在的治疗点.
科学领域:
- 心脏病学 心脏病学
- 肺高血压是什么意思 肺高血压
- 生物化学 生物化学
背景情况:
- 前毛囊性肺高血压 (precPH) 导致右心房 (RA) 压力增加和伸展.
- 在成年人中,RA是骨形态遗传蛋白10 (BMP10) 的主要来源,由心肌细胞产生.
研究的目的:
- 调查BMP10表达和分泌在右心脏和循环在precPH.
- 在prePH中确定BMP10升高的触发因素.
主要方法:
- 检查了BMP10mRNA,蛋白质以及RA组织和血中的活性.
- 使用ELISA进行循环BMP10和BRE-Luciferase转录活性测定.
- 与RA扩张,右心室 (RV) 功能和NTproBNP水平相关的BMP10.
- 在CTEPH患者的肺内关节切除术 (PEA) 后评估BMP10活性变化.
主要成果:
- 在前PH RA中,BMP10 mRNA,蛋白质和活性显著增加.
- 观察到循环中的BMP10蛋白水平升高,但转录活性没有显著差异.
- 高BMP10活性与RA扩张相关,RA压力增加,NTproBNP升高,RV射出分数减少.
- 在CTEPH患者中,压力卸载后PEA导致BMP10活性降低.
结论:
- 在前PH中,RA BMP10表达和血水平增加,可能是由于RA扩张和压力过载.
- 需要进一步的研究来确定BMP10升高是否是适应性或治疗点.
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