城市化和宿主亲属关系塑造了广泛传播的一般性食肉动物中的病毒组合
Natalie Payne1, Desiree Andersen1, Cheryl Mollohan2
1School of Natural Resources and the Environment, University of Arizona, Tucson, Arizona, USA.
Molecular ecology
|February 24, 2025
概括
城市猫携带病毒,可以在野生动物和家禽之间传播. 主体遗传学和城市化影响鱼病毒组合,特别是在雌性动物中,突出显示了野生地区与城市界面 (WUI) 疾病传播风险.
科学领域:
- 生态生态学 生态生态学
- 病毒学 病毒学
- 基因组学就是基因组学.
背景情况:
- 城市野生动物可以在野生动物和城市界面 (WUI) 之间传播野生动物,人类和家禽之间的疾病.
- 影响城市野生动物中病原体群落的因素,特别是猫 (Lynx rufus) 中的病毒,尚未得到充分研究.
- 了解这些动态对于管理疾病的出现和跨物种传播至关重要.
研究的目的:
- 在WUI研究塑造猫病毒组合的因素.
- 整合宿主基因组,GPS和病毒组数据以识别病毒社区结构的驱动因素.
- 评估宿主遗传学和城市化在病毒病原体存在中的作用.
主要方法:
- 采集了使用混合捕获方法从鱼便和口腔抹布收集的DNA和RNA病毒组数据.
- 集成的病毒组数据与宿主基因组相关性和GPS跟踪数据.
- 利用统计模型分析病毒组合和病毒分类分布与宿主和环境因素的关系.
主要成果:
- 在猫中鉴定出多种病毒,包括犬类帕尔沃病毒,猫类天文病毒,Felis catus乳头瘤病毒和里昂-IARC多重瘤病毒.
- 主体遗传关系和城市化因素 (城市土地覆盖面,道路/建筑密度,道路距离) 显著影响了鱼病毒组合.
- 与病毒组合的遗传关联在雌性猫中更强,显示病毒多样性和遗传距离之间的相关性.
结论:
- 这项研究是首次评估野生动物病毒组合构成的因素.
- 在WUI港口的猫拥有已知的猫和狗病原体,这表明跨物种传播的可能性.
- 城市化和宿主遗传学在塑造猫病毒群体方面发挥着重要作用,观察到的性别特异性模式.
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