全球关于以患者为中心的结果的观点:在全球范围内推进以患者为中心的癌症临床试验
Cecilia Monge1,2, Linsey Eldridge1, Paul C Pearlman1
1Center for Global Health, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
Journal of the National Cancer Institute. Monographs
|February 24, 2025
概括
以患者为中心的临床试验通过关注患者价值观来改善癌症护理. 在资源较低的国家加强患者参与和数据收集,可以改善全球癌症研究和公平获取.
科学领域:
- 在瘤学瘤学.
- 临床试验 临床试验
- 医疗保健服务研究 医疗服务研究
- 全球健康 全球健康
背景情况:
- 以患者为中心的临床试验优先考虑患者的经验和结果,这对癌症治疗至关重要.
- 以患者为中心的结果研究 (PCOR) 为个性化和有效的癌症治疗策略提供了证据.
- 整合患者的观点对于推动全球癌症护理至关重要.
研究的目的:
- 在全球癌症临床试验中探索以患者为中心的方法的重要性.
- 确定在低收入和中等收入国家 (LMICs) 患者参与的挑战和机会,并整合患者报告的结果 (PROs).
- 倡导全球平等获得以患者为中心的癌症护理.
主要方法:
- 文献综述和综合以患者为中心的临床试验当前的做法.
- 分析障碍 (例如基础设施,资金) 和促进患者参与LMICs的促进因素.
- 讨论加强LMIC研究能力和监管协调的战略.
主要成果:
- 在LMICs中存在重大障碍,包括研究基础设施和资金有限.
- 机遇在于创新战略,基础设施投资和监管协调.
- 实质性的患者参与和PRO的整合在LMIC中至关重要,但具有挑战性.
结论:
- 克服LMICs中的障碍对于进行高质量,以患者为中心的癌症研究至关重要.
- 投资于研究基础设施和协调可以提高LMIC解决全球癌症负担的能力.
- 将以患者为中心的护理和研究扩展到服务不足的人群中,促进了全球癌症公平.
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