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以泡分散方法使用Ezetimibe口服固体脂质纳米颗粒:在小鼠体内进行了体外表征和体内药物动力学研究

Ruba S Darweesh1, Farah S Al-Qawasmi1, Mai S Khanfar1

  • 1Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.

Pharmaceutical development and technology
|February 24, 2025
PubMed
概括

埃泽胺固体脂质纳米颗粒 (SLN) 是为了提高溶解性和生物可用性而开发的. 优化的EZT-SLNs显示,与纯粹的ezetimibe相比,在体外释放和体内吸收增强.

关键词:
这样一来,你可能会有更多的机会.没有形状的无形.生物可用性 生物可用性分散的分散性分散.药物动力学 药物动力学固体脂质纳米粒子 固体脂质纳米粒子

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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