在体外检查微导管在超动脉放射栓塞中微球注射期间的微导管行为
Tess Josien Snoeijink1,2, Jan Lucas van der Hoek2, Hadi Mirgolbabaee2,3
1Department of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.
概括
在跨动脉放射栓塞 (TARE) 微球注射期间的导管运动显著影响了治疗的交付. 标准化注射技术对于一致的微球分布和改善TARE结果至关重要.
科学领域:
- 干预性放射学 干预性放射学
- 医学物理 医学物理
- 生物医学工程 生物医学工程
背景情况:
- 跨动脉放射栓塞 (TARE) 是一种使用放射性微球治疗肝癌的方法.
- 微球的精确传递对于治疗疗效和最大限度地减少目标外辐射至关重要.
- 在注射期间的微导管行为可以影响微球分布.
研究的目的:
- 为了实验性地研究TARE微球注射期间的微导管行为.
- 分析导管运动对微球分布在分叉模型中的影响.
主要方法:
- 使用了一种体外模型,其中有一个三倍分叉的幻影.
- 使用临床微导管和刚性控制器注射了模仿血液的液体和Holmium-165微球.
- 追踪了导管运动,并分析了8个出口的微球分布.
主要成果:
- 脉冲注射导致显著的临床微导管运动 (高达0.87毫米的位移).
- 与刚性对照相比,导管运动导致了微球分布的改变 (75.9%对1-4出口的49.4%).
结论:
- 在TARE微球注射期间的临床微导管运动会影响分布.
- 脉冲注射型增加了导管运动,可能会损害预测工具的准确性.
- 标准化TARE注射技术可能会减少变异性,并提高微球分布的可预测性.
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