来自海洋衍生真菌的生物活性类固醇:一篇评论 (2015-2023)
Xue-Yang Ma1,2, Huan-Nan Wang2, Li-Xiang Sun1,2
1School of Pharmacy, Binzhou Medical University, Yantai264003, China.
Journal of Asian natural products research
|February 24, 2025
概括
海洋真菌产生具有显著生物活性的新型类固醇. 这篇评论强调了175种海洋真菌类固醇,其中74种在抗菌和抗瘤研究等领域显示出药物开发的前景.
科学领域:
- 海洋生物学 海洋生物学
- 自然产品化学 自然产品化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 海洋真菌是独特的二次代谢产物的丰富来源.
- 来自海洋真菌的类固醇具有不同的药理性质.
- 这些化合物对于发现新型治疗药物的发现有价值.
研究的目的:
- 审查海洋真菌类固醇的结构多样性和生物活性.
- 为了确定这些化合物的来源和应用.
- 为类固醇药物开发提供线索.
主要方法:
- 在2015年至2023年期间发表的海洋真菌类固醇的文献搜索.
- 分析结构特征和报告的生物活性.
- 基于真菌属和海洋息地的化合物的分类.
主要成果:
- 确定了175种海洋真菌类固醇,主要来自Aspergillus,Penicillium和Talaromyces属.
- 化合物从各种海洋环境中分离出来,包括海藻,红树林,沉积物,海绵和珊瑚.
- 74种类固醇表现出显著的生物活性,包括抗菌,抗瘤,酶抑制和抗病毒作用.
结论:
- 海洋真菌类固醇是新药发现的丰富资源.
- 鉴定到的生物活性为开发新药品提供了有希望的线索.
- 对海洋真菌代谢物的进一步研究可以促进制药科学的发展.
相关概念视频
01:19Mesenchymal Stem Cells
4.6K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.6K
01:30Prodrugs
2.4K
Prodrugs are a class of pharmaceutical compounds that undergo a biotransformation process within the body to be converted into a pharmacologically active drug. Prodrugs are designed to improve the therapeutic properties of the parent drug, such as enhancing bioavailability, increasing stability, or reducing toxicity. The concept of prodrugs revolves around modifying the chemical structure of the original drug to make it more effective or convenient for administration.
Prodrugs help overcome...
Prodrugs help overcome...
2.4K