阿迪波涅丁信号调节尿膀功能,通过使光滑肌肉的纯能收缩性变得,从而调节尿膀功能
Zhaobo Luo1, Ali Wu1, Simon Robson2,3
1Division of Nephrology.
JCI insight
|February 24, 2025
概括
下尿道症状 (LUTS) 与肥胖有关. 这项研究揭示了阿迪波涅丁 (ADPN) 信号影响膀功能,这表明一种新的途径有助于代谢综合征中的LUTS.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 代谢综合征研究 代谢综合征研究
- 分子生物学分子生物学
背景情况:
- 下尿道症状 (LUTS) 影响超过50%的40岁以上的成年人,并与肥胖和代谢综合征密切相关.
- 脂肪组织释放的阿迪波金调节新陈代谢和炎症;阿迪波涅丁 (ADPN) 是一种具有胰岛素敏感性和抗炎性质的关键阿迪波金.
- 目前尚不清楚ADPN在与代谢综合征相关的LUTS中的作用.
研究的目的:
- 调查阿迪波涅丁 (ADPN) 在与肥胖和代谢综合征相关的下尿道症状 (LUTS) 中的潜在作用.
- 通过使用全球ADPN淘汰赛小鼠模型,检查ADPN信号在膀平滑肌 (BSM) 收缩中的功能.
主要方法:
- 使用全球ADPN-knockout (Adpn-/-) 鼠标来评估膀功能和收缩性.
- 在Adpn-/-小鼠中分析了代谢和纯能途径.
- 研究了ADPN受体激动剂AdipoRon和AMPK调节器对BSM收缩性的影响.
主要成果:
- Adpn-/-小鼠表现出尿动频率增加,空腔体积较小,膀光滑肌 (BSM) 收缩率显著降低,特别是缺乏纯能收缩.
- 分子分析显示Adpn-/-小鼠的代谢和纯能途径发生了显著的改变.
- ADPN受体激动剂AdipoRon以及AMPK激活剂和抑制剂都消除了急性BSM纯能收缩.
结论:
- 一个新的ADPN信号通路显著促进了BSM收缩性的调节.
- 这种ADPN信号通路的失调可能是肥胖和代谢综合征中LUTS的关键机制.
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