阶段恢复子像素图像注册:在福里埃域光学连贯断层扫描中增强运动检测性能
Huakun Li1, Bingyao Tan2,3,4, Vimal Prabhu Pandiyan5
1School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, Singapore, Singapore.
Journal of physics D: Applied physics
|February 24, 2025
概括
细胞运动的相位敏感里埃域光学连贯性断层扫描 (FD-OCT) 成像得到了新的相位恢复子像素图像注册 (PRESIR) 方法的改进. 这种技术可以减少噪音,提高动作检测的灵敏度和准确性.
科学领域:
- 生物医学光学 生物医学光学
- 医疗成像医学成像
- 眼科医生 眼科 眼科
背景情况:
- 阶段敏感的里埃域光学连贯性断层扫描 (FD-OCT) 允许无标签的细胞动态在体内成像,具有纳米级的灵敏度.
- 功能性成像模式,如光线图谱 (ORG),多普勒OCT和光学连贯弹性图形利用FD-OCT进行细胞运动检测.
- 在体内FD-OCT成像中,相框间位移引入了脱关系噪声,降低了运动检测的灵敏度和准确性.
研究的目的:
- 开发和验证一种方法来纠正FD-OCT中与位移相关的折叠关系噪声.
- 用FD-OCT提高体内细胞运动检测的灵敏度和准确性.
- 为了恢复在OCT成像中被运动工件损害的相位信息.
主要方法:
- 提出了一种基于一般FD-OCT模型的新型相位恢复子像素图像注册 (PRESIR) 方法.
- 在保持相位信息的同时,PRESIR可以实现复杂值的OCT图像的子像素精度翻译转移.
- 该方法纠正光谱 (k) 域中的轴位移和空间频率域中的横位位移.
主要成果:
- 在FD-OCT中,PRESIR方法有效地纠正了与位移相关的折叠关系噪声.
- 在动物和人类的模拟,幻影实验和体内光网膜学 (ORG) 验证了该方法的性能.
- 达到接近信号与噪声比率定义的理论极限的相位灵敏度,显著减少移动样品中的噪声.
结论:
- 在FD-OCT成像中,PRESIR方法提供了运动工件的准确校正.
- 这种技术显著提高了 in vivo 细胞运动检测的灵敏度和准确性.
- PRESIR推进了功能成像模式,依赖于动态生物组织的精确相位测量.
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