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Irianiwati Irianiwati¹, Thela Calcarina Gurky¹, Sumadi Lukman Anwar²

¹Department of Anatomical Pathology, Faculty of Medicine, Public Health and Nursing, University Gadjah Mada/Sardjito General Hospital, Sekip, Yogyakarta 55281, Indonesia.

Molecular and clinical oncology

|February 24, 2025

概括

三重阴性乳腺癌 (TNBC) 是具有侵略性的. 这项研究发现,印尼TNBC患者的负面BRCA1表达与晚期相关,但这不是一个显著的预后因素.

科学领域:

在瘤学瘤学.
遗传学是一个遗传学.
病理学病理学病理学

背景情况:

三阴性乳腺癌 (TNBC) 是一种具有不良预后的侵袭性亚型,通常影响年轻女性.
BRCA1基因突变与TNBC有关,影响对基化疗和PARP抑制剂的治疗敏感性.
了解BRCA1表达的作用对于对不同人群的预后评估至关重要.

研究的目的:

为了调查BRCA1表达在被诊断为TNBC的印度尼西亚患者的预后意义.
探索BRCA1表达,临床病理学变量和TNBC亚型之间的相关性.

主要方法:

免疫组织化学用于评估57名TNBC患者的BRCA1表达.
使用表皮生长因子受体和细胞干细胞蛋白5/6免疫染来分类TNBC亚型.
统计分析包括皮尔森的奇方位,费舍尔的精确测试和卡普兰-梅尔生存分析.

主要成果:

阴性BRCA1表达 (52.6%) 比积极表达 (47.4%) 更普遍,与晚期癌症相相关 (P=0.035).
BRCA1表达与其他临床病理变量或治疗类型没有相关性.
阶段 (P=0.091) 和BRCA1表达 (P=0.150) 并不是这一队列中生存的显著预后因素.

结论:

负的BRCA1表达与印尼TNBC患者的晚期病例有关.
在本研究队列中,BRCA1表达没有被证明是显著的预后因素.
需要进一步的研究,以充分阐明BRCA1在特定族群中TNBC预后中的作用.

关键词:

在BRCA1表达过程中,预后因素是一个预后因素.幸存率幸存率生存率三重阴性乳腺癌是什么

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