儿童的性食道炎:一项多中心研究评估了墨西哥当前的做法
Victor Gonzalez-Uribe1,2,3, Luis A Hernandez-Zarate2, Cesar F Pozo Beltran4
1Pediatric Allergy & Clinical Immunology Service, Hospital Infantil de Mexico Federico Gomez, Universidad Nacional Autónoma de Mexico, Cuauhtemoc, Mexico City, Mexico.
The journal of allergy and clinical immunology. Global
|February 24, 2025
概括
在儿童中诊断异敏性食道炎 (EoE) 是具有挑战性的,延迟很常见. 这项研究在大多数儿科EOE患者中发现了IgG4阳性细胞,dupilumab对治疗有希望.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 免疫学 免疫学 免疫学
- 过敏 过敏是一种过敏.
背景情况:
- 性食道炎 (EoE) 是一种影响食道的慢性免疫疾病,导致儿童出现各种症状和诊断挑战.
- 目前儿科EoE的诊断和治疗实践显示出显著的变化.
研究的目的:
- 评估墨西哥儿科EoE的诊断和治疗策略.
- 为了确定儿童中EoE常见的临床表现.
- 研究IgG4在儿科EOE中的作用.
主要方法:
- 对32名被诊断患有EoE的儿科患者进行了回顾性分析.
- 数据收集包括临床症状,内镜和组织学发现,以及过敏评估.
- 在食道活检中评估IgG4阳性血细胞.
主要成果:
- 患者的平均年龄为10.6岁,诊断延迟的平均时间为15.5个月.
- 食物受损是最常见的症状,82%的人有过亚托皮病史.
- 在83.8%的活检中组织学确认了EoE;在76.5%的患者中发现了IgG4阳性血细胞.
- 杜皮卢马布治疗导致显著的临床改善.
结论:
- 在诊断和管理儿科EoE方面仍然存在挑战,需要标准化的方法.
- IgG4 的存在表明它可能在 EoE 病理生理学中发挥作用.
- 需要进一步的研究来制定治疗指南并确认dupilumab的疗效.
相关概念视频
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
229
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
229
Gastroesophageal Reflux Disease II: Clinical Features and Management
45
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
45
Barrett Esophagus-II: Clinical Manifestations and Management
97
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
97
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
79
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
79


