罕见的化真菌代谢物和来自内性真菌Nigrospora sp的α-pyrones
Chika C Abba1, Peter M Eze2,3, Sherif S Ebada4
1Department of Pharmaceutical and Medicinal Chemistry, Nnamdi Azikiwe University, Awka 420261, Nigeria.
ACS omega
|February 24, 2025
概括
来自*Gongronema latifolium*的内菌产生了新的化合物. 提取物显示出抗氧化和抗微生物特性,突出了药物开发的潜力.
科学领域:
- 微生物学 微生物学
- 自然产品化学 自然产品化学
- 药理学是指药理学,即药理学是指药理学.
背景情况:
- 内生菌微生物是生物活性二次代谢产物的宝贵来源.
- 植物 *Gongronema latifolium* 是一个丰富的潜在微生物内细胞的来源.
研究的目的:
- 为了研究内性 *Nigrospora* sp. 的二次代谢产物. 从 *Gongronema latifolium * * 中分离出来.
- 评估真菌提取物和分离化合物的抗氧化和抗微生物活性.
主要方法:
- 菌的隔离,识别,发酵和提取.
- DPPH抗氧化剂测定和阿加井扩散测定用于生物活性查.
- 染色学和光谱技术用于化合物隔离和表征.
主要成果:
- 原始提取物表现出中度的抗氧化活性 (48%的抑制在500μg/mL) 和对* Bacillus subtilis*和* Salmonella typhi*的抗菌活性.
- 他们分离了六种化合物:阿克罗登胺 (一种罕见的化代谢物) 和五种α-pyrone衍生物.
- 自1993年首次发现以来,阿克罗登西奥胺被报道仅为第二次.
结论:
- 植物内 *Nigrospora* sp. 在内体内 产生具有潜在制药应用的生物活性二次代谢物.
- 由于它们已知的生物活性,这些分离的化合物,包括阿克罗登胺和α-皮龙,需要进一步研究药物开发.
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