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分子球形核酸的生物评估:通过基于混合的叶酸装饰来向瘤

Tatsiana Auchynnikava^1,2, Antti Äärelä^2,3, Olli Moisio¹

¹Turku PET Centre, University of Turku and Turku University Hospital, Turku FI-20520, Finland.

|February 24, 2025

概括

用叶酸装饰的球形核酸在FR表达瘤中显示增加积累. 这种有针对性的交付突出了它们在癌症治疗和诊断方面的潜力.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
在瘤学瘤学.

背景情况:

叶酸受体 (FRs) 在许多癌症中过度表达,使它们成为药物输送的有吸引力的目标.
分子球状核酸 (MSNA) 在传递应用中比传统的寡核酸具有潜在的优势.

研究的目的:

开发和评估叶酸装饰的MSNA用于针对FR过度表达乳腺癌异体移植的向输送.
评估这些新型纳米载体的生物分布和瘤积累.

主要方法:

用叶酸装饰的MSNA的组装和用-18 (18F) 进行特定地点的放射性标记.
在携带HCC1954乳腺癌异种移植的小鼠中使用PET/CT成像进行体内评估.
对叶酸装饰的MSNAs与非装饰的MSNAs的生物分布和瘤与肌肉的比率的分析.

主要成果:

与未装饰的MSNA相比,叶酸装饰的MSNA在FR表达器官 (肝脏,脏,脏) 中积累更高,瘤与肌肉的比率改善.
这种增强的吸收对于具有酸 (PO) 骨干的MSNA结构具有统计学意义.
通过PET/CT成像,成功监测了18F放射标记的MSNAs的生物分布.

结论:

叶酸装饰增强了MSNAs对FR过度表达瘤的有针对性的输送.
这些装饰着叶酸的MSNA显示出作为癌症治疗和诊断的向输送工具的潜力.
在实现统计学上显著的准有效性方面,PO骨干是至关重要的.

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