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Updated: May 26, 2025

Rapid In Vivo Fixation and Isolation of Translational Complexes from Eukaryotic Cells
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改进阿米迪诺-罗卡拉特到eIF4A1的RNA紧的结构基础

James F Conley1, Lauren E Brown2, James H McNeely2

  • 1Department of Pharmacology, Physiology & Biophysics, Boston University, Boston, Massachusetts 02215, United States.

ACS omega
|February 24, 2025
PubMed
概括

阿米迪诺-罗卡格拉特 (ADRs) 通过更有效地将真核细胞启动因子4A-1 (eIF4A1) 紧到RNA上来增强翻译抑制. 这种提高的功效源于ADRs的刚性结构,预先组织它们以最佳地结合eIF4A1.1.

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