息肉的解剖学分布在男性和女性不同,便测试呈阳性
Joseph C Anderson1,2, William M Hisey3,4, Christina M Robinson3,4
1Geisel School of Medicine at Dartmouth Hanover New Hampshire USA.
阳性便检测增加了两性中晚期的息肉检测. 然而,排便检测阳性的男性显示左侧晚期病变的增加较大,与女性不同,这表明结直肠癌查中的性别特异性差异.
科学领域:
- 胃肠病学 胃肠病学
- 结肠直肠癌查 结肠直肠癌查
- 流行病学 流行病学
背景情况:
- 结肠直肠癌 (CRC) 查旨在检测晚期瘤.
- 便测试,包括便DNA (mt-sDNA) 和便免疫化学测试 (FIT),用于CRC查.
- 了解结肠位置,性别和查史的病变检测差异对于优化内镜术实践至关重要.
研究的目的:
- 为了比较男性和女性之间右结肠和左结肠中晚期瘤的几率.
- 根据先前阳性便检测结果与仅结肠镜查的差异来评估差异.
- 为了告知内镜实践关于性别和查的CRC检测基于变化.
主要方法:
- 主要结局:在结肠镜检查过程中检测到晚期病变 (晚期腺瘤,晚期状多,CRC).
- 研究人群:接受结肠镜检查的男性和女性,根据先前的查史进行分类 (便检测阳性与仅结肠镜检查).
- 统计分析:逻辑回归用于根据结肠位置,性别和查队列比较先进病变的调整几率.
主要成果:
- 与仅接受结肠镜检查的患者相比,检测阳性患者在整个结肠中出现晚期病变的几率更高,而不论性别.
- 仅接受结肠镜检查的男性显示右侧与左侧高级病变的几率更高 (OR:1.87).
- 在便检测阳性的男性中,晚期病变的几率因结肠位置而没有显著差异 (mt-sDNA+:OR 0.63;FIT+:OR 0.50,与仅进行结肠镜检查的男性相比).
- 检测阳性的女性在右结肠和左结肠之间的晚期病变几率中没有显著差异.
结论:
- 阳性便检测与在男性和女性中增加左侧和右侧高级息肉的检测有关.
- 与右侧相比,便测试呈阳性的男性在左侧结肠中晚期病变的增加显著更高.
- 在正面便测试的女性中,没有观察到右结肠和左结肠之间的晚期病变几率增加的显著差异.
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