在伊莱尔克罗恩病的内镜和组织病理学评估之间的不一致
Scott D Lee1, Brian Mau2, Cody J Avalos1
1Department of Gastroenterology, School of Medicine, University of Washington, Seattle, WA 98195, United States.
内镜和组织学评估之间的不一致性是常见的伊莱尔克罗恩病 (CD). 协议化活检甚至在的边缘也显示出炎症,这凸显了改善诊断策略的必要性.
科学领域:
- 胃肠病学 胃肠病学
- 炎症性肠道疾病研究研究
- 诊断病理学的诊断病理学
背景情况:
- 在克罗恩病 (CD) 中,内镜和组织学评估显示出不一致.
- 这种不一致的患病率和原因尚不清楚.
研究的目的:
- 评估标准化活检方案是否有助于理解叶CD的评估不一致性.
- 为了研究内镜检测结果与终端大肠膜组织学炎症之间的关系.
主要方法:
- 患有阴道CD的患者接受了结肠镜检查和内镜评估.
- 从的边缘和周围的粘膜 (7mm,14mm) 或对照中的随机部位收集了protocolized活检.
- 一位盲目的病理学家使用验证的炎症组织学指数分析了活检.
主要成果:
- 在患有的患者中,只有67%的边活检显示有活性的炎症;33%表明/侵蚀,主要是大.
- 没有的对照没有显示/侵蚀,但8%有活跃的炎症.
- 在内镜外观和组织学发现之间观察到显著的不一致.
结论:
- 活跃的阴茎CD中炎症的内镜和组织学评估之间存在显著的不一致,即使是有针对性的活检.
- 在没有疾病活动的内镜迹象的患者中发现了更高的一致性.
- 需要进一步的研究来优化活检协议,并将组织学发现纳入CD治疗.
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