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在双向内镜检查中,添加到普罗波福的向受控输液中的埃托米达的作用:一项随机临床试验

Hui-Rong Luo¹, An-Di Chen², Jing-Fang Lin²

¹Department of Anesthesiology, Fujian Medical University Union Hospital, Fuzhou 350000, Fujian Province, China.

World journal of gastrointestinal endoscopy

|February 24, 2025

概括

在内镜检查中,添加埃托米达酸到普罗波福的目标控制输液 (TCI) 镇静剂可以提高安全性和满意度. 乙胺0.15mg/kg组的不良事件较少,并且减少了醇的使用.

科学领域:

麻醉学麻醉学
胃肠病学胃肠病学
药理学药理学是指药理学的学科.

背景情况:

普罗波在胃肠内镜镇静中很常见,但会导致心血管和呼吸系统问题.
可能需要更高剂量的普罗波的目标控制输注 (TCI).
埃托米达提供了血液动力学稳定性.

研究的目的:

为了评估在双向内镜检查期间不同剂量埃托米达与普罗波TCI结合的影响.
评估不同埃托米达特-普罗波镇静方案中的安全性和有效性参数.

主要方法:

330名患者被随机分为三个组:单独使用普罗波TCI (P),或使用普罗波TCI与0.1 mg/kg (0.1EP) 或0.15 mg/kg (0.15EP) etomidate.
普罗波TCI在3.0毫克/毫升的效果部位度开始使用.
在Propofol TCI之前,Etomidate被静脉注射.

主要成果:

与P (78 mmHg,36.4%) 和0.1EP (82 mmHg,29.1%) 组相比,0.15EP组保持了更高的平均血压 (88 mmHg),并且降低了低血压发生率 (11.8%).
在0.15EP组 (201.2毫克) 中,普罗波的摄入量最低,诱导时间 (1.1分钟) 和恢复时间 (3.9分钟) 较短.
0.15EP组的呼吸抑制和注射疼痛较少,同时患者,内镜医生和麻醉师的满意度更高.

结论:

0.15 mg/kg的埃托米达与普罗波TCI结合,显著降低了对普罗波的需求.
这种组合导致心血管不良事件减少,呼吸系统抑郁减少.
以0.15mg/kg的埃托米达治疗方案提高了患者和医务人员的整体满意度.

关键词:

不良反应不良反应双向内镜检查是一种双向内镜检查.埃托米酸是一种普罗波福尔 (Propofol) 是一种目标控制输注注射目标控制输注

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