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相关概念视频

Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
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The Thyroid Gland01:23

The Thyroid Gland

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The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
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Functions of Thyroid Hormones01:18

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The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
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相关实验视频

Updated: May 26, 2025

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
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布罗利祖马布诱导的甲状腺风暴

Ewelina Niedzialkowska1, Lark Steafo1, Sam Alsabti1

  • 1Department of Internal Medicine, Corewell Health William Beaumont University Hospital, Royal Oak, Michigan, USA.

Proceedings (Baylor University. Medical Center)
|February 24, 2025
PubMed
概括
此摘要是机器生成的。

免疫检查点抑制剂 (ICI) 可以引起罕见但严重的甲状腺风暴. 这一案例突出了一个患有卵巢癌的患者,在接受布罗利祖马布治疗后发生了甲状腺风暴,强调需要保持警.

关键词:
免疫检查点抑制剂 免疫检查点抑制剂这就是Pembrolizumab.甲状腺风暴是因为甲状腺风暴.

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科学领域:

  • 在瘤学瘤学.
  • 内分泌学 在内分泌学.
  • 免疫学 免疫学 免疫学

背景情况:

  • 免疫检查点抑制剂 (ICI) 是革命性的癌症治疗方法.
  • 免疫相关的不良反应 (irAEs) 是ICI常见的副作用,通常涉及内分泌系统疾病.
  • 甲状腺功能障碍发生在13-14%的接受 pembrolizumab 治疗的患者中,但甲状腺风暴非常罕见.

研究的目的:

  • 报告一种极为罕见的甲状腺风暴病例,该病例发生在接受布罗利祖马布治疗的患者身上.
  • 突出ICI治疗可能导致严重内分泌并发症的可能性.

主要方法:

  • 一个34岁的女性患有转移性卵巢癌的病例报告.
  • 作为治疗方案的一部分,佩布罗利祖马布的使用.
  • 观察患者的临床表现和甲状腺风暴的发展.

主要成果:

  • 患者在添加pembrolizumab后不久就出现了甲状腺风暴.
  • 这代表了与ICI治疗相关的极为罕见的不良事件.

结论:

  • 甲状腺风暴是一种罕见但关键的免疫相关的不良影响 pembrolizumab.
  • 临床医生应在接受ICI的患者中保持对严重内分泌事件的高度怀疑指数.