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整合孟德尔的随机化与因果媒介,分析特征直接和间接暴露于外部效应的分析

Fan Yang1,2, Lin S Chen3, Shahram Oveisgharan4

  • 1Yau Mathematical Sciences Center, Tsinghua University.

The annals of applied statistics
|February 24, 2025
PubMed
概括

综合门德尔随机化和调解分析 (IMMA) 将大型GWAS数据与个人级数据相结合,以分辨心房动对阿尔茨海默氏症痴呆的直接和间接影响. 这种方法揭示了AF直接增加痴呆风险,但通过抗凝剂治疗间接降低痴呆风险.

关键词:
门德尔的随机化因果调解分析因果调解分析综合性分析是一种综合性分析.

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