基于微藻的细菌用于口服治疗ASD,通过增强肠道殖民和恒温
Rongrong Yang1,2,3,4, Li Ma2,5, Huan Peng2,3,4
1Department of Psychiatry, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.
Theranostics
|February 24, 2025
概括
螺旋藻增强了有益细菌的肠道殖民,如Lactobacillus reuteri,通过调节肠-大脑轴来改善小鼠的自闭症谱系障碍 (ASD) 症状.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 生物技术是生物技术.
背景情况:
- 有益的肠道细菌可以通过肠-大脑相互作用改善自闭症谱系障碍 (ASD) 等精神疾病.
- 像Lactobacillus reuteri (L. reuteri) 这样的细菌的有限肠道殖民限制了它们在ASD的治疗应用.
研究的目的:
- 开发一种新的输送系统,使用Spirulina platensis (SP) 作为微载体来增强肠道细菌殖民.
- 在ASD小鼠模型中评估SP-L. reuteri的疗效.
主要方法:
- 乳杆菌reuteri被绑定到螺旋藻 platensis,以创建SP-L. reuteri. 的时间.
- 在SP-L. reuteri的殖民效率被评估为ex vivo和in vivo.
- 在ASD小鼠模型中评估了SP-L. reuteri对社会缺陷的治疗效果.
主要成果:
- SP有效地结合并释放细菌,增强肠道殖民.
- 与单独的L. reuteri相比,SP-L. reuteri表现出优越的殖民化.
- 通过改善肠道微生物群,屏障功能和减少神经炎症,SP-L. reuteri减轻了ASD小鼠的社会缺陷.
结论:
- 斯皮鲁琳娜白菜 (Spirulina platensis) 作为肠道细菌传递的有效微载体.
- 这种微藻辅助系统增强了与肠-大脑轴相关的疾病的细菌移植.
- SP-L. reuteri系统在治疗自闭症和其他肠道相关疾病方面表现有前途.
相关概念视频
01:19Autism Spectrum Disorder
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
01:30Development of Human Microbiota
The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...
01:27The Oral Microbiota
The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
01:28Development of the Oral Microbiota
The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
01:22Gut-Brain Axis
The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such as...
01:21Microbiota Modulation by Antibiotics
Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...