基于神经元功能的血管认知障碍的血液生物标志物:系统性审查和元分析
Weiquan Huang1, Libin Liao1, Qian Liu2
1Department of General Practice, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, Jiangsu, China.
Frontiers in neurology
|February 24, 2025
概括
血液检查显示出检测血管认知障碍 (VCI) 的前景. 关键生物标志物如粉样β和神经丝光可以区分VCI患者,有助于早期诊断和预后.
科学领域:
- 神经学 神经学
- 生物化学 生物化学
- 老年学是一门学科.
背景情况:
- 血管认知障碍 (VCI) 是导致痴呆的主要原因,与血管问题有关.
- 血液生物标志物越来越多地被用于VCI检测和预后.
- 脑血管疾病和血管风险因素是VCI的主要驱动因素.
研究的目的:
- 进行对血液生物标志物进行评估的元分析,以检测VCI.
- 评估与神经元功能相关的九种外围生物标志物的潜力.
主要方法:
- 在四个主要数据库 (PubMed,Embase,Web of Science,Cochrane Library) 进行系统的文献搜索,截至2023年12月31日.
- 包括30项研究从4043个已识别的文章.
- 对9个生物标志物的分析:Aβ42,Aβ40,Aβ42/Aβ40比率,t-Tau,p-tau 181,NfL,BDNF,S100B,以及sRAGE.
主要成果:
- 周围粉样蛋白β 42 (Aβ42),Aβ42 / Aβ40比率,神经丝光 (NfL) 和S100B显示了VCI和非VCI组之间的显著差异.
- 这些生物标志物表明在区分具有VCI的个体方面具有潜在的实用性.
结论:
- 特定的血液生物标志物,包括Aβ42,Aβ42/Aβ40比率,NfL和S100B,显示了VCI的诊断潜力.
- 进一步的研究可以验证这些发现在VCI诊断和管理中的临床应用.
相关概念视频
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