病毒参与口腔潜在恶性疾病:一个范围审查
Khalid Sulthoni Zahid1, Wahyu Hidayat2, Dewi Zakiawati2
1Undergraduate Program in Dental Medicine, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia.
Cancer management and research
|February 24, 2025
概括
这次审查发现,在口腔潜在恶性疾病 (OPMDs) 中,病毒的流行率很高,包括HPV,EBV,HBV和HSV. 虽然病毒有助于OPMD病因,但烟草仍然是主要的风险因素,需要进一步研究病毒诱导的恶性转变.
科学领域:
- 口腔病理学 口腔病理学
- 病毒学 病毒学
- 在瘤学瘤学.
背景情况:
- 口腔潜在恶性疾病 (OPMDs) 是口腔癌的前体,是一个重大的全球健康问题.
- 了解OPMD的病因对于早期检测和预防策略至关重要.
- 病毒越来越多地与各种癌症的发展和进展有关.
研究的目的:
- 进行范围审查,识别与OPMD相关的病毒,除了HPV和EBV.
- 确定病毒是否有助于OPMD的初始发展 (病因),其恶性转变,或两者兼而有之.
- 综合当前关于OPMDs病毒作用的研究.
主要方法:
- 根据PRISMA-ScR框架进行了范围审查.
- 在 EBSCOhost 和 PubMed 数据库中进行了全面的文献搜索.
- 包括2014年至2023年间发表的研究,重点关注OPMD中检测到的病毒,分析病毒类型,检测方法和患者人口统计等特征.
主要成果:
- 28篇文章符合纳入标准,显示OPMD中检测到的病毒的流行率为78.57%.
- 通常检测到的病毒包括HPV (086.6%),EBV (895.7%),乙型肝炎病毒 (HBV) (6.71%),以及简单疹病毒 (HSV) (1%).
- 在本次审查中,烟草使用被确定为OPMD最重要的风险因素.
结论:
- 像HPV,EBV,HBV和HSV这样的病毒,以及烟草和酒精等生活方式因素,在OPMD的病因和进展中发挥着作用.
- 病毒的流行程度在地理位置上有所不同,并且可能涉及共同感染和与生活方式的相互作用,从而影响致癌潜力.
- 虽然口腔状细胞癌 (OSCC) 和OPMD的病毒阳性性较高,但病毒患病率很高,恶性转变的直接因果关系需要进一步调查.
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