认知功能与神经精神疾病之间的关系与长期COVID综合征患者的定量脑电图 (qEEG)
Yetty Ramli1,2, Pukovisa Prawiroharjo1,2, Winnugroho Wiratman1,2
1Department of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Brain, behavior, & immunity - health
|February 24, 2025
概括
长期COVID患者表现出显著的认知缺陷,特别是在记忆和改变大脑连接方面. 这些发现凸显了COVID-19对神经和心理健康的持久影响,包括大脑雾.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 传染性疾病 传染性疾病
背景情况:
- 长期COVID综合征是COVID-19的后果,具有鲜为人知的神经和精神效应.
- 评估持久的心理健康影响,包括认知和神经生理变化,对于理解长期COVID至关重要.
- 这项研究调查了长期COVID患者的常见精神障碍.
研究的目的:
- 评估长期COVID患者的认知和神经生理方面的情况.
- 将长期COVID患者与没有残留症状从COVID-19中恢复过来的患者进行比较.
- 为了确定与长期COVID相关的持久心理健康影响.
主要方法:
- 一项横截面研究,将长期COVID患者与无症状COVID-19康复个体进行比较.
- 定量脑电图 (qEEG) 分析,包括大脑光谱检查,半球不对称性和电极之间的连接.
- 通过蒙特利尔认知评估 (MoCA) 进行认知评估,并通过自我评价问卷 (SRQ) 进行心理评估.
主要成果:
- 与对照组相比,长期COVID患者在记忆领域的MoCA得分明显较低.
- 在qEEG频谱检查或两组之间的半球不对称性中没有发现统计差异.
- 连接性分析显示,在长期COVID组中,形-形 (T6-O2) 连接性显著更高.
结论:
- 在长期的COVID中,COVID-19具有持续的神经精神病学影响,特别是认知缺陷和改变的大脑连接.
- 工作记忆缺陷是长期COVID患者经常出现的神经心理症状.
- 大脑连接性下降与认知感官运动衰退和长期COVID中观察到的"脑雾"症状相关.
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