应用于新型炎症指标的应用价值,以应对原发性胆道胆道炎患者的乌尔索多西胆酸治疗
Siqi Liu1, Yongli Pang2, Xiaoxi Wang3
1Inner Mongolia Medical University, Hohhot, Inner Mongoli, People's Republic of China.
International journal of general medicine
|February 24, 2025
概括
像淋巴细胞/单细胞比率 (LMR) 和中性粒细胞/淋巴细胞比率 (NLR) 这样的新型炎症指标可以预测接受ursodeoxycholic acid (UDCA) 的初级胆道胆炎 (PBC) 患者的治疗反应. 低的LMR和高的NLR表明对UDCA治疗的反应较差.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 临床免疫学临床免疫学
- 生物标志物发现发现
背景情况:
- 原发性胆道胆炎 (PBC) 是一种慢性肝病.
- Ursodeoxycholic 酸 (UDCA) 是PBC的主要治疗方法.
- 评估UDCA治疗反应对于患者管理至关重要.
研究的目的:
- 评估新型炎症指标的有用性:淋巴细胞/单细胞比率 (LMR),中性粒细胞/淋巴细胞比率 (NLR) 和血小板/淋巴细胞比率 (PLR).
- 确定用于评估PBC患者UDCA治疗反应的简单方法.
- 为了将这些炎症标志物与治疗结果相关联.
主要方法:
- 在PBC患者和对照人群中,对例行血液检查,肝功能和维生素D (VD) 水平进行了回顾性分析.
- 对LMR,NLR和PLR的计算.
- 根据巴黎I标准,将PBC患者分为良好和不良反应组.
- 接收器运行特征 (ROC) 分析以确定预测值.
主要成果:
- 与对照组相比,PBC患者的LMR和VD水平显著降低.
- 具有良好的UDCA反应的患者比反应差的患者显示出更高的LMR和更低的NLR.
- ROC分析表明LMR (AUC=0.682) 和NLR (AUC=0.630) 的预测值.
- 在PBC患者中,PLR和VD水平之间发现了显著的负相关性.
结论:
- 低的LMR和高的NLR是PBC中UDCA治疗反应不佳的潜在指标.
- PLR也可能对治疗反应具有预测价值.
- 这些炎症标志物提供了一种方便的方法来评估UDCA的疗效.
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