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Updated: May 26, 2025

Monitoring eIF4F Assembly by Measuring eIF4E-eIF4G Interaction in Live Cells
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Monitoring eIF4F Assembly by Measuring eIF4E-eIF4G Interaction in Live Cells

Published on: May 1, 2020

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欧核细胞翻译启动因子eIF4E的转录后活动有助于HoxA9驱动的白血病发生

Fang Zhou1,2,3, Biljana Culjkovic-Kraljacic4,5, Christian Bach2,3

  • 1Department of Hematology and Oncology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 210009, P.R. China.

bioRxiv : the preprint server for biology
|February 24, 2025
PubMed
概括

HoxA9与eIF4E的相互作用,而不是其转录活性,驱动急性髓性白血病 (AML) 的发展. 破坏这种相互作用令人惊地延迟了AML的发病,揭示了eIF4E对AML患者的新治疗标.

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