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Updated: May 26, 2025

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
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空间上不同的细胞和分子景观定义了三重阴性乳腺癌的预后

Kavitha Mukund1, Darya Veraksa1, David Frankhouser2

  • 1Department of Bioengineering, UC San Diego, Gilman Drive, La Jolla, CA 92093, USA.

bioRxiv : the preprint server for biology
|February 24, 2025
PubMed
概括

空间转录学揭示了与患者预后相关的三阴性乳腺癌 (TNBC) 的明显分子概况. 这些发现为改善这种侵袭性癌症的诊断和向治疗提供了潜力.

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Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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