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Updated: May 7, 2026

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
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单细胞分辨率追踪皮肤T细胞淋巴瘤揭示了疾病进展中的克隆进化

Hannah K Dorando, Jared M Andrews, Nicholas C Borcherding

    bioRxiv : the preprint server for biology
    |February 24, 2025
    PubMed
    概括

    这项研究揭示了推动皮肤T细胞淋巴瘤 (CTCL) 进展的关键分子变化,确定了CCR4,PI3K,PD-1和STAT3通路中的突变. 这些发现为治疗这种具有挑战性的癌症提供了新的目标.

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    T Cell Activation and Clonal Selection01:22

    T Cell Activation and Clonal Selection

    T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
    Naive T cells that have not yet encountered an antigen express two primary CD...