性取决于行为配置的调节通过腹部标记区域-核核的状电路
bioRxiv : the preprint server for biology
|February 24, 2025
概括
腹膜区域 (VTA) 到核 (AcbSh) 电路影响行为分配. 激活这个电路在雄性和雌性动物中改变了寻求奖励的行为,这表明它是成治疗的目标.
科学领域:
- 神经科学是一个神经科学.
- 行为科学 行为科学
- 成研究 研究成研究
背景情况:
- 药物使用障碍涉及对药物使用的不适应性行为分配.
- 控制这种行为分配的特定神经回路仍然不完全理解.
研究的目的:
- 为了研究中层神经回路的作用,特别是腹膜区域 (VTA) 到核 (AcbSh) 路径,在行为分配中.
- 评估VTA-AcbSh电路激活对自然和药物奖励寻求的性别依赖影响.
主要方法:
- 在动物中使用化学遗传学方法,设计者受体仅由设计者药物 (DREADDs) 激活.
- 采用并发选择自我管理模式来评估自然 (糖) 和药物 (可卡因) 奖励之间的行为分配.
- 在VTA-AcbSh神经元中药理上激活的DREADDs.
主要成果:
- 激活VTA-AcbSh电路导致行为分配的性别依赖性变化.
- 雄性动物对自然奖励的追求增加,而雌性动物对药物奖励的追求减少.
- 连续DREADD激活证实了VTA-AcbSh电路在加强对并发奖励的响应中的作用.
结论:
- VTA-AcbSh电路在行为分配的基本过程中发挥了关键作用.
- 这种电路是开发用于药物使用障碍的新药疗法的重要目标.
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