改变功能网络能量跨多层次大脑网络在早产期和全产期受试者:从青少年大脑认知发展 (ABCD) 研究的见解
Qiang Li1, Dawn Jensen1,2, Zening Fu1
1Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, GA, United States.
bioRxiv : the preprint server for biology
|February 24, 2025
概括
早产改变了青少年的大脑连接,显示了视觉,感觉运动和认知网络的差异. 满期婴儿显示出更动态的脑网络,而早产婴儿显示出更大的稳定性但更少的灵活性.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 大脑连接研究研究大脑连接研究
背景情况:
- 过早出生 (早产) 的婴儿可能由于发育不完全而改变了大脑连接.
- 这些人可以在青春期表现出持续的结构和功能性大脑差异,与全年同龄人相比.
研究的目的:
- 检查在早产和满期青少年的多尺度功能连接的功能网络能量.
- 为了确定大脑网络与早产和满期受试者之间的网络能量有显著差异.
主要方法:
- 分析跨多尺度功能连接的功能网络能量.
- 在青少年大脑认知发展 (ABCD) 研究中利用了大约4600名青少年的数据.
- 在视觉,感觉运动和高认知网络中,在早产和长期组之间比较网络能量.
主要成果:
- 三个关键的大脑网络 (视觉,感官运动,高认知) 在早产和满期青少年之间的网络能量中显示出显著的差异.
- 长期受试者表现出更大的网络不稳定性,动态重新配置和灵活性.
- 前期受试者表现出更稳定的网络,但功能性大脑组织不那么动态和灵活.
结论:
- 多尺度功能网络能量测量提供了对早产儿规范大脑网络稳定性的洞察.
- 早产影响大脑发育,影响关键神经网络的稳定性和灵活性.
- 这些发现提高了对早产如何影响青少年大脑组织的理解.
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