目前研究人类休息状态功能在炎症性肠病中的方法
Theresa A McIver1,2,3, Charles N Bernstein1,2,3, Jennifer Kornelsen1,2,4
1Department of Radiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
Journal of the Canadian Association of Gastroenterology
|February 24, 2025
概括
休息状态功能磁共振成像 (rs-fMRI) 显示在炎症性肠病 (IBD) 中大脑功能发生变化. 这些大脑变化可能作为开发新的IBD治疗方法的生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 医疗成像医学成像
背景情况:
- 炎症性肠病 (IBD),包括克罗恩氏病和性结肠炎,涉及慢性胃肠道炎症与相关的心理和认知问题.
- 大脑-肠轴在IBD中发挥着至关重要的作用,研究越来越多地关注了解IBD相关的大脑变化.
- 休息状态的大脑功能,反映自发的神经活动,是研究的一个关键领域.
研究的目的:
- 通过静止状态功能磁共振成像 (rs-fMRI) 审查目前研究IBD静止状态大脑功能的方法.
- 要总结通常识别的脑区域和网络,在IBD患者中表现出异常功能.
- 概述未来的研究方向,以推进IBD中大脑功能的研究.
主要方法:
- 对人类休息状态功能性磁共振成像 (rs-fMRI) 在炎症性肠道疾病 (IBD) 的研究进行审查.
- 对各种静止状态指标的分析,包括区域均性和低频波动的幅度.
- 检查功能连接分析,如独立组件分析和图形理论.
主要成果:
- 休息状态功能磁共振成像 (rs-fMRI) 研究表明,在患有炎症性肠病 (IBD) 的个体中,休息时大脑功能发生变化.
- 特定的大脑区域和网络通常在IBD中表现出异常功能.
- 研究方法的变化,包括参与者特征和分析方法,会影响研究结果.
结论:
- 在IBD中改变静止状态大脑功能表明潜在的神经生物标志物用于治疗开发.
- 方法的标准化和进一步的多模式研究是必要的,以促进理解.
- 在IBD中研究大脑-肠轴对新的治疗策略有前途.
相关概念视频
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
295
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
295
01:17Irritable Bowel Syndrome I: Introduction
219
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
219
01:17Chronic Bowel Disorders: Introduction
378
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
378
01:29Inflammatory Bowel Disease IV: Pharmacological Management
89
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
89
01:30Inflammatory Bowel Disease II: Crohn's Disease
158
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
158
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
114
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
114