怀孕期间的血液动态及其与产科并发症的关联:一个回顾性队列研究
Veronica Tozzo1,2,3, Rachel Petherbridge1,2, Kaitlyn James4
1Department of Pathology and Center for Systems Biology, Massachusetts General Hospital, Boston, MA, USA.
medRxiv : the preprint server for health sciences
|February 24, 2025
概括
怀孕期间红细胞数量增加,特别是显著增加,与产科并发症的风险更高有关. 这些发现有助于为孕妇的全血细胞计数建立新的参考间隔.
科学领域:
- 产科和妇科 产科和妇科
- 血液学 血液学 血液学
- 生殖医学 生殖医学
背景情况:
- 怀孕显著改变了血液学参数,需要更新全血计数 (CBC) 的参考间隔.
- 怀孕期间CBCs的现有参考间隔可能不准确地反映不同人群的纵向变化.
研究的目的:
- 在一个大型的美国队列中,为CBC及其纵向变化建立妊娠年龄特定的参考间隔.
- 调查CBC极端值与产科并发症的变化之间的关联.
主要方法:
- 从1998年至2022年使用电子健康记录的回顾性队列研究.
- 包括发现和验证队列,包括超过96,000个单独怀孕.
- 使用概括估计方程分析CBC指数和综合产科结果.
主要成果:
- 血红素,血红素和红细胞计数值升高与复合产科并发症风险增加有关.
- 怀孕期间血红蛋白和红细胞数量的显著增加与早产风险更高相关.
- 确定的参考间隔往往比一些CBC指数先前公布的值更宽.
结论:
- 较高的红细胞计数和这些指标在怀孕期间大幅增加与不良的产科结果有关.
- 该研究为完善诊断标准和监测孕妇提供了关键数据.
更多相关视频
05:31Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
Published on: January 26, 2024
742
12:17The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
Published on: August 2, 2017
10.5K
相关概念视频
Rh Blood Group
1.3K
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
1.3K
Hematopoiesis
5.0K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
5.0K
Teratogenicity
2.3K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.3K
Oogenesis
63.3K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.3K
