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在狭窄的QRS复合体中QRS 3D电压时间积分 - - 确定正常的参考范围
Amulya Gupta1, Christopher J Harvey1, Uzair Mahmood2
1Department of Cardiovascular Medicine, University of Kansas Medical Center, Kansas City, KS.
在健康成年人中建立了矢量心脏学3D QRS电压-时间积分 (VTIQRS-3D) 参考范围. VTIQRS-3D值受到年龄和性别的影响,需要考虑临床使用.
科学领域:
- 心脏病学 心脏病学
- 生物医学工程 生物医学工程
- 医学诊断 医学诊断 医学诊断
背景情况:
- 矢量心脏学3D QRS电压-时间积分 (VTIQRS-3D) 是一种用于心室失调的新型标记.
- 它的临床实用性对心脏再同步治疗有希望,但正常参考范围尚未定义.
- 确定这些范围对于准确的解释至关重要.
研究的目的:
- 在健康的成年人群中定义VTIQRS-3D的正常参考范围.
- 研究年龄和性别对VTIQRS-3D值的影响.
- 为使用VTIQRS-3D作为诊断标记物提供基础.
主要方法:
- 从健康成年人和患有减少射出分数 (EF <50%) 的患者的12导电图的回顾性分析.
- 使用Kors矩阵将12导电心电图转换为向量心脏指导,用于QRS持续时间≤120毫秒.
- 计算VTIQRS-3D,并根据性别和年龄组分层的参考范围 (2.5至97.5百分位数) 的确定.
主要成果:
- 该研究包括468名健康成年人和314名心肌病患者.
- VTIQRS-3D在心肌病患者 (48.2±21.4μVs) 和健康个体 (38.1±9.3μVs) 中显著更高.
- 增加的年龄和女性性别是健康个体中较低VTIQRS-3D的显著预测因素,已建立年龄和性别特定的参考范围.
结论:
- VTIQRS-3D在年轻人,男性和患有减排分数心肌病的患者中较高.
- 在解释VTIQRS-3D值时必须考虑年龄和性别.
- 定义的参考范围促进了VTIQRS-3D用于检测结构性心脏病的临床应用.
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