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结质瘤化学或放射治疗耐药性的研究趋势:一个文献计量分析 (2003-2023)

Shishi Yu¹, Jinya Wu¹, Yuan Jing¹

¹The Editorial Department of the Journal of Southern Medical University, Southern Medical University, Guangzhou, Guangdong, China.

Frontiers in oncology

|February 24, 2025

概括

这种图书统计分析揭示了质瘤化学或放射治疗耐药性研究的显著增加,将重点转移到瘤微环境和免疫调节. 像雄激素受体这样的新兴标显示出未来治疗策略的前景.

科学领域:

神经瘤学神经瘤学
癌症研究癌症研究
免疫治疗是一种免疫疗法.

背景情况:

质瘤是一种主要的中枢神经系统恶性瘤,具有重大的治疗耐药性挑战.
瘤微环境 (TME) 和免疫调节是质瘤进展和治疗耐药性的关键因素.
过去二十年来对质瘤化学或放射性疗法耐药性研究进行全面的文献分析是缺乏的.

研究的目的:

系统地评估质瘤化学或放射治疗耐药性的研究环境.
确定新兴的研究热点和有影响力的贡献.
为这个领域的未来研究方向提供指导.

主要方法:

在Web of Science核心收藏中对2003-2023年间的4,528篇出版物进行了图书统计分析.
使用VOSviewer,CiteSpace和R包 (bibliometrix,ggplot2) 进行网络和趋势分析.
分析了合著,关键词演变和引文爆发,以绘制研究模式.

主要成果:

从2013年至2022年期间观察到显著的出版物增长,在2022年达到顶峰.
研究重点从"MGMT基因"转移到"瘤微环境"",免疫透"和"纳米粒子".
雄激素受体被确定为一个有希望的,但尚未探索的治疗标.

结论:

质瘤化学或放射治疗耐药性的研究正在迅速扩大,强调免疫调节和TME.
这项研究提供了第一个全面的文献统计概述,突出了关键趋势和未来的方向.
加强国际合作和多学科方法对于克服质瘤治疗耐药性至关重要.

关键词:

受体受体是受体的受体.文献计量分析的分析化学或放射治疗耐药性耐药性质瘤质瘤是一种免疫透免疫透是什么?瘤微环境是一个微环境.

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