专尿和淋巴膜过率与事件脆弱性之间的关联
Elisa K Bongetti1,2, Anna L Wilkinson3,4,5, James B Wetmore6
1Department of Nephrology, Monash Medical Centre, Monash Health, Melbourne, Victoria, Australia.
Kidney international reports
|February 24, 2025
概括
低和高估计的淋巴膜过率 (eGFR) 都会增加健康老年人的虚弱风险. 用尿中的白蛋白与肌素比率 (UACR) 表示的白蛋白尿,也独立预测脆弱性.
科学领域:
- 老年学是一门学科.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 流行病学 流行病学
背景情况:
- 在健康的老年人中,功能标志物与脆弱性之间的关系尚未得到充分理解.
- 使用估计的膜过率 (eGFR) 和通过尿液白蛋白与肌素比率 (UACR) 评估功能对于老年人的健康至关重要.
- 虚弱是老年人群不良健康结果的重要预测因素.
研究的目的:
- 调查基线eGFR和UACR与健康老年人的事件脆弱性之间的关联.
- 通过两种不同的脆弱性评估方法来评估这些关联:修改的炸脆弱性表型 (FP) 和赤字积累脆弱性指数 (FI).
主要方法:
- 对ASPirin在减少老年人 (ASPREE) 随机试验队列中的二次分析.随机试验队列.
- 包括来自澳大利亚和美国的65岁以上独立,健康的老年人.
- 离散时间生存分析,以检查事件脆弱的时间.
主要成果:
- 在eGFR和事件脆弱性 (FP和FI) 之间观察到非线性关系.
- 显著增加的脆弱性风险与eGFR<30毫升/分钟/1.73米2或eGFR≥95毫升/分钟/1.73米2有关.
- 每一次基线UACR翻一番,就会增加4%的事件脆弱性风险,而不论脆弱性评估方法如何.
结论:
- 降低和升高的EGFR水平都与老年健康成年人患虚弱的风险增加有关.
- 升高的UACR,即使在低水平,也与事件脆弱性独立相关.
- 这些发现强调了监测功能在老年人群脆弱性评估的背景下的重要性.
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