系统性免疫炎症指数与成年女性压力尿失禁之间的关联:基于人口的研究
Mei Jiang1, Xiaodie Yao1, Hua Jiang1
1Department of Gynecology and Obstetrics, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing, People's Republic of China.
International journal of women's health
|February 24, 2025
概括
该研究发现,较高的全身免疫炎症指数 (SII) 水平与女性压力尿失禁 (SUI) 风险增加之间存在联系. 这表明炎症可能在SUI发展中发挥作用.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 炎症与压力尿失禁 (SUI) 的病因有关.
- 系统性免疫炎症指数 (SII) 是一种新的炎症标志物.
- 在女性中SII和SUI之间的关联需要进一步研究.
研究的目的:
- 探索成年女性的全身免疫炎症指数 (SII) 和压力尿失禁 (SUI) 之间的关联.
- 调查炎症在SUI发展中的潜在作用,如SII所示.
主要方法:
- 从2007-2018年NHANES数据集中对成年参与者的分析.
- 进行了加权的多变量逻辑回归和子组分析.
- 限制立方线和两部分逻辑回归评估了非线性关系和拐点.
主要成果:
- 在SII和SUI风险之间发现了显著的积极关联 (OR:1.09;P=0.021).
- 与最低三位数相比,SII三位数最高的女性的SUI风险增加了15% (OR:1.15,P=0.049).
- 观察到一种非线性关系,SII随着SII的增加而增加SUI风险,直到8.64.4的拐点.
结论:
- 较高的SII水平与女性SUI的可能性增加有关.
- 研究结果表明,炎症可能有助于SUI的发病.
- 需要进一步的前性研究来证实这些结果.
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