与2型糖尿病和心血管风险相关的血清加列-3和纤维细胞生长因子-23水平
Aleksandra Klisic1, Sanja Gluscevic2, Paschalis Karakasis3
1University of Montenegro-Faculty of Medicine, Podgorica, Montenegro.
在2型糖尿病 (T2D) 患者中血清 galectin-3 含量升高,与FGF-23相关. 虽然这两种生物标志物都显示出与心血管风险评分的联系,但需要进一步的研究来确认它们与心血管疾病的独立关联.
科学领域:
- 生物标志物 生物标志物
- 内分泌学 在内分泌学.
- 心血管疾病 心血管疾病
背景情况:
- 在2型糖尿病 (T2D) 和心血管风险中,加勒-3和FGF-23的临床效用尚不清楚,因为之前的研究存在矛盾.
- 之前的研究表明,与T2D和心血管风险相关的加勒-3和FGF-23的发现有所不同.
研究的目的:
- 调查与T2D相关的加勒-3和FGF-23.
- 为了检查加勒-3和FGF-23与动脉样硬化心血管疾病 (ASCVD) 风险评分在成年人的关联.
主要方法:
- 用ELISA测量了35名T2D患者和36名对照患者的血清 galectin-3和FGF-23水平.
- 所有参与者的动脉样硬化心血管疾病 (ASCVD) 风险评分.
主要成果:
- 与对照组相比,T2D患者的血清 galectin-3 水平显著更高 (p=0.016).
- 每增加1ng/mL的加勒-3与8.5%更高的T2D概率相关 (OR=1.085,p=0.015).
- 两组之间FGF-23水平没有差异;然而,血清中甲状蛋白-3与FGF-23相关 (r=0.390,p=0.001). 在双变量分析中,加勒-3和FGF-23都与ASCVD风险得分相关,但在逻辑回归中没有.
结论:
- 在T2D患者中,血清中甲蛋白-3水平升高,与FGF-23.3不同.
- 虽然加勒-3和FGF-23与ASCVD风险得分相关,但它们与心血管风险的独立关联没有得到证实.
- 需要进行更大的样本大小研究,以进一步阐明这些生物标志物的T2D和心血管风险中的作用.
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