多药学和药物相互作用在患有胃肠道出血的老年患者:一个单一中心回顾性研究
Tugce Uskur1, Bedriye Feyza Kurt2
1Medical Pharmacology, Kırklareli University Faculty of Medicine, Kırklareli, TUR.
Cureus
|February 24, 2025
概括
多种药物和药物相互作用显著增加老年患者的胃肠道出血风险. 评估药物治疗方案对于患者的安全和更好的结果至关重要.
科学领域:
- 老年医学 老年医学
- 胃肠病学 胃肠病学
- 临床药理学 临床药理学
背景情况:
- 胃肠道 (GI) 出血对老年患者构成重大风险.
- 并发病,多药和药物相互作用加剧了这种风险.
研究的目的:
- 为了评估在入院前六个月内因胃肠道出血而处方的药物.
- 评估老年患者 (65岁以上) 的潜在药物相互作用风险,有胃肠道出血.
主要方法:
- 对49名65岁以上的患者进行了回顾性研究,诊断出肠道出血.
- 收集的数据:人口统计,胃肠道出血类型,住院时间,结果和先前的药物治疗.
- 使用GraphPad Prism 8.0,费舍尔精确测试和奇方测试 (p<0.05) 的统计分析.
主要成果:
- 49名患者 (平均年龄为78.4±7.6岁);51%是男性. 上部胃肠道出血 (81.6%) 比下部胃肠道出血 (18.4%) 更常见.
- 死亡率为10.2%,所有死亡发生在患上上肠道上部出血的老年女性中.
- 在28名患者中发现了药物相互作用;NSAID,抗凝固剂和抗抑郁药是主要的罪祸首.
结论:
- 多药和药物相互作用是导致老年人胃肠道出血的关键因素.
- 综合药物审查和多药剂减缓策略对于患者安全至关重要.
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