对葡萄糖波动的认知脆弱性:神经退行症的数字表型
Luciana Mascarenhas Fonseca1,2, Zoë W Hawks3,4, Michal Schnaider Beeri5
1Elson S. Floyd College of Medicine, Washington State University, Spokane, Washington, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|February 24, 2025
概括
对葡萄糖 (CVG) 波动的认知脆弱性与1型糖尿病成年人的阿尔茨海默病生物标志物有关. 这表明CVG可能是神经退行症的数字生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 老年学是一门学科.
背景情况:
- 认知功能随着低血糖水平和高血糖水平的下降而下降,这表明认知对葡萄糖 (CVG) 波动的脆弱性.
- 葡萄糖可变性对老年大脑的影响尚不清楚.
- 这项研究调查了与阿尔茨海默病 (AD) 病理和神经退行相关的CVG和血生物标志物之间的关系.
研究的目的:
- 检查对葡萄糖 (CVG) 波动的认知脆弱性是否与阿尔茨海默病 (AD) 病理和神经退行症的血生物标志物有关.
- 探索CVG作为神经退行性疾病数字表型的潜力.
主要方法:
- 114名1型糖尿病成年人使用生态瞬间评估 (EMA) 来评估处理速度和持续的注意力.
- 连续血糖监测 (CGM) 与EMA同时使用.
- 分析了CVG和血生物标志物之间的关联,包括粉样β (Aβ) 42/40,酸化 (p-tau) 181和217,神经丝光链和状纤维酸性蛋白质.
主要成果:
- 对葡萄糖的认知脆弱性 (CVG) 与大多数血生物标志物有关,不包括Aβ 42/40.
- 与持续注意力相关的CVG与p-tau生物标志物 (p-tau 181和217) 显示出显著的关联.
- 即使经过对共变量进行调整后,这些关联仍然很重要.
结论:
- 对葡萄糖的认知脆弱性 (CVG) 可能成为阿尔茨海默病 (AD) 的有价值的数字表型.
- 需要进一步的研究来确定CVG是否有助于神经退行或是从中产生的.
- 讨论了将长期葡萄糖变化,认知功能和神经退行症联系在一起的潜在机制.
相关概念视频
Overview of Carbohydrate Metabolism
676
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
676
Diabetes: Symptoms, Diagnosis, and Complications
497
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
497
Pathophysiology of Diabetes
843
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
843
Cognitive Development During Adulthood
45
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
45
Hypoglycemia and Glucagon
149
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
149
Diabetes Mellitus: Type 2 and Gestational
2.1K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.1K


