在社区居住的老年人中,亚临床甲状腺功能障碍和死亡率-PolSenior研究的结果
Piotr Kocełak1, Aleksander J Owczarek2, Małgorzata Mossakowska3
1Pathophysiology Unit, Department of Pathophysiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, Katowice, Poland.
Clinical endocrinology
|February 24, 2025
概括
亚临床甲状腺功能障碍症增加了老年妇女的死亡率,而治疗的甲状腺功能障碍症改善了老年男性的生存率. 在这项为期5年的研究中,亚临床甲状腺功能低下症对生存率没有影响.
科学领域:
- 老年学是一门学科.
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 关于老年人亚临床甲状腺疾病和死亡率的数据有限.
- 甲状腺功能障碍的患病率随着年龄的增长而增加,影响整体健康.
- 了解这些影响对于老年护理和公共卫生战略至关重要.
研究的目的:
- 为了研究老年人治疗和未治疗的亚临床甲状腺功能障碍的5年总死亡率.
- 分析65岁及以上 euthyroid,hypothyroid和hyperthyroid个体之间的生存差异.
- 为了确定亚临床甲状腺疾病对死亡率的性别特异性影响.
主要方法:
- 来自PolSenior研究队列的5年死亡率数据的分析.
- 包括407名患有甲状腺疾病的参与者和2776名无甲状腺症患者 (年龄≥65岁).
- 考克斯比例危险回归和卡普兰-梅尔生存分析,按性别和甲状腺状况分层.
主要成果:
- 在女性中,亚临床甲状腺功能障碍与与甲状腺功能不良个体相比的显著更差的存活率有关.
- 在男性中,接受治疗的甲状腺功能低下症与与甲状腺功能低下症患者相比的更好的生存率有关.
- 亚临床甲状腺功能低下症对两性生存率没有显著影响.
结论:
- 亚临床甲状腺功能障碍症对老年妇女来说具有更高的死亡风险.
- 老年男性接受治疗的甲状腺功能低下症与延长生存率有关.
- 亚临床甲状腺功能低下症似乎对老年人的生存有中性的影响.
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