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调以凝为基础的水凝的室温可注射性,通过引入具有竞争力的键
Donglin Xie1, Jiang Bian1, Chao Ni1
1School of Biomedical Engineering, Shenzhen Campus of Sun Yat-sen University, Shenzhen, Guangdong 518107, P. R. China.
ACS macro letters
|February 24, 2025
概括
研究人员改善了凝的质量.
科学领域:
- 生物材料科学 生物材料科学
- 生物工程是生物工程.
- 聚合物化学 聚合物化学
背景情况:
- 凝是一种天然生物材料,具有用于生物医学应用的优良特性.
- 在室温下凝的快速固化限制了其在需要注射或3D生物打印的应用中使用.
- 开发可注射和可打印的基于凝的配方对于先进的生物工程至关重要.
研究的目的:
- 为了克服凝在室温固化的局限性.
- 为了提高凝的注射性和3D打印性,使用具有竞争力的键 (CHB) 物质.
- 研究CHB材料对凝的sol-gel过渡和质性质的影响.
主要方法:
- 引入四种具有竞争力的含键 (CHB) 的物质:甲胺,l-氨酸,聚氨酸和聚尿素.
- 调整凝的sol-gel相变温度通过CHB材料的不同度.
- 系统的风湿学测量以评估可注射性和可打印性.
- 评估3D生物打印性能,包括可打印性和形状保真性.
主要成果:
- 这四种CHB材料都有效地调整了凝的sol-gel过渡温度,以度依赖的方式.
- 添加CHB材料显著改善了凝的室温可注射性.
- 含有CHB的凝生物墨水在3D生物打印中与纯凝相比,显示出更好的打印能力和形状保真性.
结论:
- 含有竞争性键 (CHB) 的物质有效地改变了凝的热和质性质.
- 通过CHB修改的凝提供了更好的注射性和3D打印性,扩大了其在生物医学和生物工程领域的潜力.
- 这种方法为开发用于组织工程和再生医学的先进的基于凝的生物墨水提供了一种多功能战略.
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