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Updated: May 26, 2025

Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes
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在怀孕期间准确剂量拉莫特里金:生理学基础的药理动力学建模和仿真

Yudie Qian1,2,3, Wanhong Wu1,2, Chengjie Ke1,2

  • 1Department of Pharmacy, The First Affiliated Hospital, Fujian Medical University, Fuzhou, People's Republic of China.

CPT: pharmacometrics & systems pharmacology
|February 24, 2025
PubMed
概括

怀孕显著改变了lamotrigine的药理动力学 (PK),减少了药物暴露,增加了发作风险. 这项研究开发了一种PBPK模型,用于指导剂量调整,确保母亲和胎儿的安全.

关键词:
胎儿的胎儿是一个胎儿.拉莫特里奇因 (lamotrigine) 是一种基于生理学的药物动力学模型.怀孕 怀孕 怀孕 怀孕 怀孕

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Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
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