喘在阻塞性睡眠呼吸暂停中的作用是什么? 一个叙事审查
Grace Oscullo1,2,3, José Daniel Gómez-Olivas1,2,3, Francisco Javier González-Barcala2,4,5
1Servicio de Neumología, Hospital Universitario y Politécnico La Fe, Valencia, España.
概括
喘和阻塞性睡眠呼吸暂停 (OSA) 具有显著的关联,喘患者患OSA的风险高2.5倍. 这种联系凸显了在患有这两种疾病的患者中需要谨慎使用吸入性皮质类固醇的必要性.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 睡眠医学 睡眠医学
- 肺部病理学 肺部病理学
背景情况:
- 喘和阻塞性睡眠呼吸暂停 (OSA) 是非常普遍的呼吸道疾病.
- 它们在个体中的共存越来越被认为是偶然的,这表明它们是真正的关联.
研究的目的:
- 探索喘和阻塞性睡眠呼吸暂停 (OSA) 之间的关系.
- 审查这种共同疾病的病理生理学,诊断,病因学,流行病学和治疗方面.
主要方法:
- 对将喘与OSA联系起来的手稿进行系统审查.
- 对研究的分析,重点关注这两种疾病的治疗方式.
主要成果:
- 大约50%的喘患者也患有OSA.
- 喘患者患上OSA的风险增加了2.5倍,特别是那些控制不良或严重喘的人.
- 潜在的机制包括肥胖,GERD,鼻炎,鼻,喉缩性和吸入性皮质类固醇 (IC) 肌病.
结论:
- 在喘和OSA之间存在明显的一对一联系.
- 喘可能加速或恶化现有的OSA.
- 建议在OSA患者使用IC吸入技术时谨慎使用;建议使用超细颗粒来最大限度地减少喉沉积.
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